to eliminate or dispose of - possibly by destruction.
When Horace learned his cat was peeing on the rug, he zeefed it.

or

Sergeant Witmann zeefed 27 Iraqi tanks with his M1.
po Slybird Август 21, 2007
A marijuana cigarette smoked before bed to induce sleep.

A bastardization of "Zzzzz's" and "Reefer"... Like a Zeefer...Zeef for short...
My ambien wouldn't kick in, so I smoked a Zeef and dozed off quick.
po GaGa's Dentist Октобар 4, 2010

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