Top Definition
A greeting of spiritual affirmation between friends - can be used in form of "Hello" or "Goodbye".
"Bless up, brother"
"hey hey, what's going on?"

or

"See you tomorrow, mate"
"Bless up"
po VBR213 Октобар 10, 2009
1 more definition
God be with you, general wishes of well being be upon you.
'blessup yo' self foo'
po Psyda Јул 28, 2008

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