Top Definition
To have a foreign object or other obstruction in the way of personal space. It can also be used to describe an intrusion or some interruption.
"Yo, homie what you be doin' getting all up in my grillz!?"

"Hey Clarence check out those wasps all up in the grillz!"
po MP21 Септембар 26, 2009
5 Words related to Up in the grillz!

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